Thiophenol → Biphenyl

HRID 1286602Notes

Reaction equation

HRID 1286602 reaction equation
Brc1cccnc1.Sc1ccccc1>C1CCC2=NCCCN2CC1.CS(=O)(=O)[O][Pd]1(<-[NH2]c2ccccc2-c2cccc[c]21)<-[P](C1=CC=C[CH]1[Fe][CH]1C=CC=C1P(c1ccccc1)c1ccccc1)(c1ccccc1)c1ccccc1.CS(C)=O>c1ccc(Sc2cccnc2)cc1

Participants

9

Reactant 2

HCID 7969ThiophenolHCID 122863-Bromopyridine

Product 4

HCID 7095BiphenylHCID 7969ThiophenolHCID 122863-BromopyridineHCID 38136103-PHENYLTHIOPYRIDINE

Reagents, catalysts & solvents 3

HCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneReagentHCID 178505365HCID 178505365, compoundReagentHCID 679Dimethyl SulfoxideSolvent4×

Procedure

The Mosquito was used to combine the source plate solutions by multi-aspiration of 250 nL of each of the four reaction components and then to dose the resulting reaction mixture (1 uL) into a 1536-well plate

Workup

  1. additionNo procedure recorded
  2. aliquotNo procedure recorded
  3. additionNo procedure recorded

Sources & evidence

ORD record
ord-4985d0347b8b4bf79eb3bc0b29d7f6e4
Source dataset
HTE Pd-catalyzed cross-coupling screen
Original link
View source

Reaction notes

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