Propylamine → HCID 4349298, compound

HRID 128686Notes

Reaction equation

HRID 128686 reaction equation
[CH2:1]([NH2:4])[CH2:2][CH3:3].C(=O)([O-])[O-].[Cs+].[Cs+].[CH3:11][CH:12](Br)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>CN(C)C=O>[CH2:1]([NH:4][CH:12]([CH3:11])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH2:2][CH3:3]

Participants

5

Reactant 3

HCID 7852PropylamineHCID 10796Cesium carbonateHCID 11454(1-Bromoethyl)benzene

Product 1

HCID 4349298HCID 4349298, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Introduce 23 ml of propylamine into 200 ml of dimethylformamide, add 32 g of caesium carbonate and 9.25 g of α-methylbenzyl bromide. Leave for 4 hours at room temperature. Evaporate to dryness and take up with water. Extract with ethyl acetate, dry over anhydrous sodium sulphate and evaporate to dryness to obtain the expected product.

Workup

  1. customLeave for 4 hours at room temperature
  2. customEvaporate to dryness
  3. extractionExtract with ethyl acetate
  4. dry with materialdry over anhydrous sodium sulphate
  5. customevaporate to dryness

Sources & evidence

ORD record
ord-dfae9cc9acb94f7ca2a1b3598059a858
Source dataset
uspto-grants-1995_11
Patent number
US05464847

Reaction notes

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