Diethyl Malonate → Biphenyl

HRID 1286922Notes

Reaction equation

HRID 1286922 reaction equation
Brc1cccnc1.CCOC(=O)CC(=O)OCC>CC(C)c1cc(C(C)C)c(-c2ccccc2[P](C2CCCCC2)(C2CCCCC2)->[Pd]2(<-[NH2]c3ccccc3-c3cccc[c]32)[O]S(C)(=O)=O)c(C(C)C)c1.CN(C)C(=NC(C)(C)C)N(C)C.CS(C)=O>CCOC(=O)C(C(=O)OCC)c1cccnc1

Participants

9

Reactant 2

HCID 7761Diethyl MalonateHCID 122863-Bromopyridine

Product 4

HCID 7095BiphenylHCID 7761Diethyl MalonateHCID 122863-BromopyridineHCID 11310925HCID 11310925, compound

Reagents, catalysts & solvents 3

HCID 35715812-tert-Butyl-1,1,3,3-tetramethylguanidineReagentHCID 178439017HCID 178439017, compoundReagentHCID 679Dimethyl SulfoxideSolvent4×

Procedure

The Mosquito was used to combine the source plate solutions by multi-aspiration of 250 nL of each of the four reaction components and then to dose the resulting reaction mixture (1 uL) into a 1536-well plate

Workup

  1. additionNo procedure recorded
  2. aliquotNo procedure recorded
  3. additionNo procedure recorded

Sources & evidence

ORD record
ord-f3678ae0ba7843768e0c2308f5c4a251
Source dataset
HTE Pd-catalyzed cross-coupling screen
Original link
View source

Reaction notes

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