Diethyl Malonate → Biphenyl

HRID 1286929Notes

Reaction equation

HRID 1286929 reaction equation
Brc1cccnc1.CCOC(=O)CC(=O)OCC>CC(C)Oc1cccc(OC(C)C)c1-c1ccccc1[P](C1CCCCC1)(C1CCCCC1)->[Pd]1([Cl])<-[NH2]c2ccccc2-c2cccc[c]21.CCN(CC)P1(=NC(C)(C)C)N(C)CCCN1C.CS(C)=O>CCOC(=O)C(C(=O)OCC)c1cccnc1

Participants

9

Reactant 2

HCID 7761Diethyl MalonateHCID 122863-Bromopyridine

Product 4

HCID 7095BiphenylHCID 7761Diethyl MalonateHCID 122863-BromopyridineHCID 11310925HCID 11310925, compound

Reagents, catalysts & solvents 3

HCID 35138512-((1,1-Dimethylethyl)imino)-N,N-diethylhexahydro-1,3-dimethyl-2lambda5-1,3,2-diazaphosphorin-2-amineReagentHCID 178458463HCID 178458463, compoundReagentHCID 679Dimethyl SulfoxideSolvent4×

Procedure

The Mosquito was used to combine the source plate solutions by multi-aspiration of 250 nL of each of the four reaction components and then to dose the resulting reaction mixture (1 uL) into a 1536-well plate

Workup

  1. additionNo procedure recorded
  2. aliquotNo procedure recorded
  3. additionNo procedure recorded

Sources & evidence

ORD record
ord-daf4163147d24066ae7d078adb7d7a49
Source dataset
HTE Pd-catalyzed cross-coupling screen
Original link
View source

Reaction notes

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