Diethyl Malonate → Biphenyl

HRID 1286948Notes

Reaction equation

HRID 1286948 reaction equation
Brc1cccnc1.CCOC(=O)CC(=O)OCC>CC(C)(C)N=P(N1CCCC1)(N1CCCC1)N1CCCC1.CS(=O)(=O)[O][Pd]1(<-[NH2]c2ccccc2-c2cccc[c]21)<-[P](c1ccccc1N1CCOCC1)(C12C[C@H]3C[C@@H](C1)C[C@@H](C2)C3)C12C[C@H]3C[C@@H](C1)C[C@@H](C2)C3.CS(C)=O>CCOC(=O)C(C(=O)OCC)c1cccnc1

Participants

9

Reactant 2

HCID 7761Diethyl MalonateHCID 122863-Bromopyridine

Product 4

HCID 7095BiphenylHCID 7761Diethyl MalonateHCID 122863-BromopyridineHCID 11310925HCID 11310925, compound

Reagents, catalysts & solvents 3

HCID 3856267tert-Butylimino-tri(pyrrolidino)phosphoraneReagentHCID 178505364HCID 178505364, compoundReagentHCID 679Dimethyl SulfoxideSolvent4×

Procedure

The Mosquito was used to combine the source plate solutions by multi-aspiration of 250 nL of each of the four reaction components and then to dose the resulting reaction mixture (1 uL) into a 1536-well plate

Workup

  1. additionNo procedure recorded
  2. aliquotNo procedure recorded
  3. additionNo procedure recorded

Sources & evidence

ORD record
ord-b03d595bb0d64e088cbbd6c43453e9ea
Source dataset
HTE Pd-catalyzed cross-coupling screen
Original link
View source

Reaction notes

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