3-Bromopyridine → Biphenyl

HRID 1287021Notes

Reaction equation

HRID 1287021 reaction equation
Brc1cccnc1.CCOC(=O)/C=C/c1ccccc1>CC(C)c1cc(C(C)C)c(-c2ccccc2[P](C2CCCCC2)(C2CCCCC2)->[Pd]2(<-[NH2]c3ccccc3-c3cccc[c]32)[O]S(C)(=O)=O)c(C(C)C)c1.CCN=P(N=P(N(C)C)(N(C)C)N(C)C)(N(C)C)N(C)C.CS(C)=O>CCOC(=O)/C=C(\c1ccccc1)c1cccnc1

Participants

9

Reactant 2

HCID 122863-BromopyridineHCID 637758Ethyl Cinnamate

Product 4

HCID 7095BiphenylHCID 122863-BromopyridineHCID 637758Ethyl CinnamateHCID 178470870HCID 178470870, compound

Reagents, catalysts & solvents 3

HCID 33931062,N'3,N'3,N3,N3,N'5,N'5,N5,N5-nonamethyl-2,4,6-triaza-3lambda5,5lambda5-diphosphaocta-3,5-diene-3,3,5,5-tetramineReagentHCID 178439017HCID 178439017, compoundReagentHCID 679Dimethyl SulfoxideSolvent4×

Procedure

The Mosquito was used to combine the source plate solutions by multi-aspiration of 250 nL of each of the four reaction components and then to dose the resulting reaction mixture (1 uL) into a 1536-well plate

Workup

  1. additionNo procedure recorded
  2. aliquotNo procedure recorded
  3. additionNo procedure recorded

Sources & evidence

ORD record
ord-c2b2d4f1b2fc4cdb8272d5bedbda11d5
Source dataset
HTE Pd-catalyzed cross-coupling screen
Original link
View source

Reaction notes

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