3-Bromopyridine → Biphenyl

HRID 1287136Notes

Reaction equation

HRID 1287136 reaction equation
Brc1cccnc1.C#Cc1ccc(CCCC)cc1>C1CCC2=NCCCN2CC1.CS(=O)(=O)[O][Pd]1(<-[NH2]c2ccccc2-c2cccc[c]21)<-[P](c1ccccc1N1CCOCC1)(C12C[C@H]3C[C@@H](C1)C[C@@H](C2)C3)C12C[C@H]3C[C@@H](C1)C[C@@H](C2)C3.CS(C)=O>CCCCc1ccc(C#Cc2cccnc2)cc1

Participants

9

Reactant 2

HCID 122863-BromopyridineHCID 27751321-Butyl-4-ethynylbenzene

Product 4

HCID 7095BiphenylHCID 122863-BromopyridineHCID 27751321-Butyl-4-ethynylbenzeneHCID 178440834HCID 178440834, compound

Reagents, catalysts & solvents 3

HCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneReagentHCID 178505364HCID 178505364, compoundReagentHCID 679Dimethyl SulfoxideSolvent4×

Procedure

The Mosquito was used to combine the source plate solutions by multi-aspiration of 250 nL of each of the four reaction components and then to dose the resulting reaction mixture (1 uL) into a 1536-well plate

Workup

  1. additionNo procedure recorded
  2. aliquotNo procedure recorded
  3. additionNo procedure recorded

Sources & evidence

ORD record
ord-f5fc73820dda4af69dfa007eb805925e
Source dataset
HTE Pd-catalyzed cross-coupling screen
Original link
View source

Reaction notes

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