Chloroacetyl chloride → HCID 178496809, compound

HRID 1287225Notes

Reaction equation

HRID 1287225 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([NH:7][C:8](=[NH:11])[O:9][CH3:10])[CH2:3][CH2:2]1.[Cl:12][CH2:13][C:14](Cl)=[O:15].C(N(CC)CC)C>O1CCCC1>[O:1]1[CH2:6][CH2:5][N:4]([NH:7][C:8](=[N:11][C:14](=[O:15])[CH2:13][Cl:12])[O:9][CH3:10])[CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 6577Chloroacetyl chlorideHCID 8471TriethylamineHCID 178496819HCID 178496819, compound

Product 1

HCID 178496809HCID 178496809, compoundYield 98.4%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Following the procedure of Example IB, 7.2 g (0.05 mole) of the above isourea, 5.65 g (0.05 mole) of chloroacetyl chloride, 5.05 g (0.05 mole) of triethyl amine and 150 ml of tetrahydrofuran were combined to yield 11.6 g of N-morpholino-N'-(chloroacetyl)-O-methylisourea, nD30 1.4853.

Sources & evidence

ORD record
ord-e8a7d192844f49f38924cabef37d216f
Source dataset
uspto-grants-1976_10
Patent number
US03984410

Reaction notes

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