4-Chlorophenyl Isocyanate → HCID 152746817, compound

HRID 1287413Notes

Reaction equation

HRID 1287413 reaction equation
[Na].O.Cl.Cl.CN(C)CCCCC(N)=N.CN(CCCCC(N)=N)C.Cl.Cl.ClC1C=CC(N=C=O)=CC=1.Cl.Cl.[Cl:39][C:40]1[CH:45]=[CH:44][C:43]([NH:46][C:47]([NH:49][C:50](=[NH:58])[CH2:51][CH2:52][CH2:53][CH2:54][N:55]([CH3:57])[CH3:56])=[O:48])=[CH:42][CH:41]=1>C(O)(C)C.CC(C)=O>[Cl:39][C:40]1[CH:41]=[CH:42][C:43]([NH:46][C:47]([NH:49][C:50](=[NH:58])[CH2:51][CH2:52][CH2:53][CH2:54][N:55]([CH3:57])[CH3:56])=[O:48])=[CH:44][CH:45]=1

Participants

7

Reactant 4

HCID 76934-Chlorophenyl IsocyanateHCID 5360545SodiumHCID 131710477HCID 131710477, compoundHCID 178483448HCID 178483448, compound

Product 1

HCID 152746817HCID 152746817, compound

Reagents, catalysts & solvents 2

HCID 180AcetoneSolvent2×HCID 3776IsopropanolSolvent

Procedure

Following a procedure similar to that described in Example 33A but using 1.7 g. sodium in 300 ml. dry acetone, 9 g. 5-(dimethylamino)valeramidine dihydrochloride hemihydrate [m.p. 119°-120°C. (from acetonitrile)], and 5.8 g. 4-chlorophenyl isocyanate in 50 ml. dry acetone there was obtained 8.5 g. 1-(4-chlorophenyl)-3-[5-(dimethylamino)pentanimidoyl]urea dihydrochloride; m.p. 199°-200°C. (from isopropyl alcohol).

Sources & evidence

ORD record
ord-93cc4ec43bd54c38b91e7bd6059ed655
Source dataset
uspto-grants-1976_10
Patent number
US03984467

Reaction notes

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