Isopropenyl acetate → HCID 21393812, compound

HRID 1288468Notes

Reaction equation

HRID 1288468 reaction equation
[NH2:1][C:2]1[C:3]([C:12]([F:15])([F:14])[F:13])=[CH:4][CH:5]=[C:6]2[C:11]=1[CH2:10][NH:9][CH2:8][CH2:7]2.[C:16](OC(C)=C)(=[O:18])[CH3:17]>C(OCC)(=O)C>[C:16]([N:9]1[CH2:8][CH2:7][C:6]2[C:11](=[C:2]([NH2:1])[C:3]([C:12]([F:15])([F:13])[F:14])=[CH:4][CH:5]=2)[CH2:10]1)(=[O:18])[CH3:17]

Participants

4

Reactant 2

HCID 7916Isopropenyl acetateHCID 21393824HCID 21393824, compound

Product 1

HCID 21393812HCID 21393812, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

8-Amino-7-trifluoromethyl-1,2,3,4-tetrahydroisoquinoline, prepared as in Example 17, is treated with one molar equivalent of isopropenyl acetate in refluxing ethyl acetate by the procedure of Example 15 to give 2-acetyl-8-amino-7-trifluoromethyl-1,2,3,4-tetrahydroisoquinoline.

Sources & evidence

ORD record
ord-25e2f675175644ee9a0be07857d85628
Source dataset
uspto-grants-1976_10
Patent number
US03988339

Reaction notes

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