1-Bromodecane → 4-Decyloxy-3-fluorophenyl bromide

HRID 1289338Notes

Reaction equation

HRID 1289338 reaction equation
Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11].[Br:12][C:13]1[CH:18]=[CH:17][C:16]([OH:19])=[C:15]([F:20])[CH:14]=1.C(=O)([O-])[O-].[K+].[K+]>CC(=O)CC>[Br:12][C:13]1[CH:18]=[CH:17][C:16]([O:19][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH3:11])=[C:15]([F:20])[CH:14]=1

Participants

5

Reactant 3

HCID 81731-BromodecaneHCID 11430Potassium CarbonateHCID 27249814-Bromo-2-fluorophenol

Product 1

HCID 146925094-Decyloxy-3-fluorophenyl bromide

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

A solution of 1-bromodecane in butanone was added dropwise to a stirred refluxing solution of 4-bromo-2-fluorophenol and potasium carbonate. The stirred mixture was heated under reflux for 24 hr. The potassium carbonate was filtered off and the solvent removed. The product was distilled at 130° C. at 0.05 mmHg.

Workup

  1. temperatureThe stirred mixture was heated
  2. temperatureunder reflux for 24 hr
  3. filtrationThe potassium carbonate was filtered off
  4. customthe solvent removed
  5. distillationThe product was distilled at 130° C. at 0.05 mmHg

Sources & evidence

ORD record
ord-0d0eb150b336413d9098c562d198a061
Source dataset
uspto-grants-1998_05
Patent number
US05750050

Reaction notes

Loading…