Triethylamine → HCID 18921781, compound

HRID 1289498Notes

Reaction equation

HRID 1289498 reaction equation
[CH3:1][C:2]1[N:7]=[C:6]([Cl:8])[N:5]=[C:4](Cl)[CH:3]=1.[CH3:10][CH:11]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH2:14][CH2:13][NH:12]1.C(N(CC)CC)C>CN(C)C=O>[CH3:1][C:2]1[N:7]=[C:6]([Cl:8])[N:5]=[C:4]([N:12]2[CH2:13][CH2:14][C:15]3[C:20](=[CH:19][CH:18]=[CH:17][CH:16]=3)[CH:11]2[CH3:10])[CH:3]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 794712,4-Dichloro-6-methylpyrimidineHCID 922141-Methyl-1,2,3,4-tetrahydroisoquinoline

Product 1

HCID 18921781HCID 18921781, compoundYield 50.2%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In accordance with the same procedure as in Step 1 of Example 1, except that 6-methyl-2,4-dichloropyrimidine (6.52 g, 40 mmol), 1-methyl-1,2,3,4-tetrahydroisoquinoline (6.6 g, 44 mmol), triethylamine(6.8 ml, 48.8 mmol) and N,N-dimethylformamide(30 ml) were used as starting materials, 5.5 g of the titled compound was prepared. (Yield: 50.2%)

Sources & evidence

ORD record
ord-6eb65fa6d9c6462f83f6dc1d35b9121e
Source dataset
uspto-grants-1998_05
Patent number
US05750531

Reaction notes

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