HCID 178518333, compound → HCID 178518397, compound

HRID 1289533Notes

Reaction equation

HRID 1289533 reaction equation
[OH:1][C:2]1[N:11]=[C:10]([OH:12])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1>O=[Pt]=O.FC(F)(F)C(O)=O>[OH:1][C:2]1[N:11]=[C:10]([OH:12])[C:9]2[CH2:8][CH2:7][CH2:6][CH2:5][C:4]=2[N:3]=1

Participants

4

Reactant 1

HCID 178518333HCID 178518333, compound

Product 1

HCID 178518397HCID 178518397, compoundYield 34.5%

Reagents, catalysts & solvents 2

HCID 345198Adams' catalystCatalystHCID 6422Trifluoroacetic acidSolvent

Procedure

A mixture solution of 2,4-dihydroxyquinazoline(39.2 g, 0.24 mol), platinium oxide(4 g) and trifluoroacetic acid(300 ml) was hydrogenated by Parr reactor for 2 hours. Platinium was filtered and the filtrate was concentrated, diluted with water, and basified with 1N-NaOH solution. The resulting solid was filtered and dried to give 13.76 g of the titled compound. (Yield: 34.5%)

Workup

  1. filtrationPlatinium was filtered
  2. concentrationthe filtrate was concentrated
  3. additiondiluted with water
  4. filtrationThe resulting solid was filtered
  5. customdried

Sources & evidence

ORD record
ord-6e0409b4965f422ba5086c69b30bbe3e
Source dataset
uspto-grants-1998_05
Patent number
US05750531

Reaction notes

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