N-Methylaniline → HCID 69956318, compound

HRID 1289536Notes

Reaction equation

HRID 1289536 reaction equation
[CH3:1][NH:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[CH3:9][CH:10]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH2:13][CH2:12][N:11]1[C:20]1[C:29]2[CH2:28][CH2:27][CH2:26][CH2:25][C:24]=2[N:23]=[C:22]([Cl:30])[N:21]=1>CN(C)C=O>[ClH:30].[CH3:1][N:2]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1)[C:22]1[N:21]=[C:20]([N:11]2[CH2:12][CH2:13][C:14]3[C:19](=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH:10]2[CH3:9])[C:29]2[CH2:28][CH2:27][CH2:26][CH2:25][C:24]=2[N:23]=1

Participants

4

Reactant 2

HCID 7515N-MethylanilineHCID 18921711HCID 18921711, compound

Product 1

HCID 69956318HCID 69956318, compoundYield 26%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

After N-methylaniline(0.50 ml, 4.8 mmol) was added to a mixture solution of 4-(1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl)-2-chloro-5,6,7,8-tetrahydroquinazoline(0.75 g, 2.40 mmol) and dimethylformamide(5 ml), 0.26 g of the titled compound was obtained in accordance with the same procedure as in Step 2 of Example 1.

Sources & evidence

ORD record
ord-4117309df4bb4d5f8c29afa70b5630eb
Source dataset
uspto-grants-1998_05
Patent number
US05750531

Reaction notes

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