Triethylamine → HCID 18921720, compound

HRID 1289566Notes

Reaction equation

HRID 1289566 reaction equation
C(N(CC)CC)C.[Cl:8][C:9]1[N:14]=[C:13](Cl)[C:12]([CH3:16])=[C:11]([CH2:17][CH3:18])[N:10]=1.[CH3:19][CH:20]1[C:25]2[S:26][CH:27]=[CH:28][C:24]=2[CH2:23][CH2:22][NH:21]1>CN(C)C=O>[CH3:16][C:12]1[C:13]([N:21]2[CH2:22][CH2:23][C:24]3[CH:28]=[CH:27][S:26][C:25]=3[CH:20]2[CH3:19])=[N:14][C:9]([Cl:8])=[N:10][C:11]=1[CH2:17][CH3:18]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 145481697-Methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridineHCID 18921712HCID 18921712, compound

Product 1

HCID 18921720HCID 18921720, compoundYield 51.4%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In accordance with the same procedure as in Step 1 of Example 1, except that triethylamine(2.2 ml), N,N-dimethyl formamide(20 ml), 2,4-dichloro-5-methyl-6-ethylpyrimidine (2.7 g, 14.1 mmol) prepared in Preparation 4 and 7-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine(2.4 g, 15.7 mmol) prepared in Preparation 1 were used as starting materials, 2.23 g of the titled compound was prepared. (Yield: 51.3%)

Workup

  1. customprepared in Preparation 1

Sources & evidence

ORD record
ord-dc3120a0493f4b6a9b53f17cb049c6d7
Source dataset
uspto-grants-1998_05
Patent number
US05750531

Reaction notes

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