N-Methylaniline → HCID 67627202, compound

HRID 1289580Notes

Reaction equation

HRID 1289580 reaction equation
[CH3:1][NH:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[CH2:9]([C:11]1[N:16]=[C:15]([N:17]2[CH2:26][CH2:25][C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[CH2:18]2)[N:14]=[C:13]([Cl:27])[CH:12]=1)[CH3:10]>CN(C)C=O>[ClH:27].[CH2:9]([C:11]1[N:16]=[C:15]([N:17]2[CH2:26][CH2:25][C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[CH2:18]2)[N:14]=[C:13]([N:2]([C:3]2[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=2)[CH3:1])[CH:12]=1)[CH3:10]

Participants

4

Reactant 2

HCID 7515N-MethylanilineHCID 18921804HCID 18921804, compound

Product 1

HCID 67627202HCID 67627202, compoundYield 13.2%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

After N-methylaniline(0.10 ml, 9.22 mmol) was added to a mixture solution of 6-ethyl-2-(1,2,3,4-tetrahydroisoquinolin-2-yl)-4-chloropyrimidine(1.20 g, 4.38 mmol) and dimethylformamide(10 ml), 0.22 g of the titled compound was obtained in accordance with the same procedure as in Step 4 of Example 57.

Sources & evidence

ORD record
ord-713a17f53c89418f99acb7603a6706e9
Source dataset
uspto-grants-1998_05
Patent number
US05750531

Reaction notes

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