Carbon Disulfide → 5-Hydroxypentyl isothiocyanate

HRID 1289793Notes

Reaction equation

HRID 1289793 reaction equation
[OH:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][NH2:7].[C:8](=S)=[S:9].C(N(CC)CC)C.C(Cl)(=O)OCC>C(Cl)(Cl)Cl>[OH:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][N:7]=[C:8]=[S:9]

Participants

6

Reactant 4

HCID 6348Carbon DisulfideHCID 8471Triethylamine2×HCID 10928Ethyl chloroformateHCID 756345-Aminopentan-1-ol

Product 1

HCID 104869815-Hydroxypentyl isothiocyanate

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

The synthesis method of Example 45-(1) was applied. 5-Hydroxypentylamine (6.00 g), carbon disulfide (40 ml), triethylamine (8.3 ml), ethyl chlorocarbonate (5.4 ml), triethylamine (8.3 ml) and chloroform (20 ml) were used as reagents. After the reaction, a yellow liquid was quantitatively obtained.

Workup

  1. customThe synthesis method of Example 45-(1)
  2. customAfter the reaction
  3. customa yellow liquid was quantitatively obtained

Sources & evidence

ORD record
ord-8df58fab982b4bcdb01a58c3cde4623e
Source dataset
uspto-grants-1998_05
Patent number
US05750545

Reaction notes

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