Dimethylformamide → HCID 22885701, compound

HRID 1289959Notes

Reaction equation

HRID 1289959 reaction equation
[F:1][C:2]([F:35])([F:34])[C:3]1[CH:4]=[C:5]([C@H:13]([O:15][C@H:16]2[CH2:20][CH2:19][C@@H:18]([N:21]([CH2:23][C:24](O)=[O:25])[CH3:22])[C@@H:17]2[C:27]2[CH:32]=[CH:31][C:30]([F:33])=[CH:29][CH:28]=2)[CH3:14])[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1.CN(C=O)C.C(Cl)(=O)C([Cl:44])=O>C(Cl)Cl>[F:1][C:2]([F:35])([F:34])[C:3]1[CH:4]=[C:5]([C@H:13]([O:15][C@H:16]2[CH2:20][CH2:19][C@@H:18]([N:21]([CH2:23][C:24]([Cl:44])=[O:25])[CH3:22])[C@@H:17]2[C:27]2[CH:32]=[CH:31][C:30]([F:33])=[CH:29][CH:28]=2)[CH3:14])[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1

Participants

5

Reactant 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 22885700HCID 22885700, compound

Product 1

HCID 22885701HCID 22885701, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The residue from Step B was taken up in methylene chloride and a trace of DMF was added followed by 0.21 mL of oxalyl chloride. The reaction was stirred at room temperature for 1 h and then evaporated and used in Step D.

Workup

  1. customevaporated

Sources & evidence

ORD record
ord-95ddcc31c776468381f1bf0326c3a2c6
Source dataset
uspto-grants-1998_05
Patent number
US05750549

Reaction notes

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