Diisopropylethylamine → HCID 131719851, compound

HRID 1290386Notes

Reaction equation

HRID 1290386 reaction equation
[CH3:1][N:2]1[C:7](=[S:8])[NH:6][C:5](=[O:9])[C:4](=[O:10])[NH:3]1.FC(F)(F)S(O[CH2:17][C@@H:18]1[O:22][CH2:21][C@@H:20]([S:23][C:24](=[O:26])[CH3:25])[CH2:19]1)(=O)=O.CCN(C(C)C)C(C)C>O1CCCC1.CN(C)C=O>[CH3:1][N:2]1[CH:7]([S:8][CH2:17][C@@H:18]2[O:22][CH2:21][C@@H:20]([S:23][C:24](=[O:26])[CH3:25])[CH2:19]2)[NH:6][C:5](=[O:9])[C:4](=[O:10])[NH:3]1

Participants

6

Reactant 3

HCID 81531DiisopropylethylamineHCID 30346402-Methyl-3-sulfanyl-1,2-dihydro-1,2,4-triazine-5,6-dioneHCID 86750748Ethanethioic acid trans(+/-)-S-[tetrahydro-5-[[[(trifluoromethyl)sulfonyl]oxy]methyl]-3-furanyl]ester

Product 1

HCID 131719851HCID 131719851, compoundYield 32.3%

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 8028TetrahydrofuranSolvent2×

Procedure

The title compound is prepared by the procedure of Example 23 using 0.551 g of product from Example 83 in 1 ml of tetrahydrofuran, 1.07 g of product from Example 22 in 1 ml of tetrahydrofuran, 3 ml of dimethylformamide, and 605 microliter of Hunig's base to give 0.357 g of the desired product.

Sources & evidence

ORD record
ord-4fe0fac76d9c4bd3840c62d33c168f07
Source dataset
uspto-grants-1998_05
Patent number
US05750735

Reaction notes

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