反应详情

Methylbromoacetate (2,75 g, 18 mmol) was added dropwise to a solution of benzhydrylpiperazin (4.5 g, 18 mmol) in THF (150 ml). The reaction was stirred for 30 minutes at room temperature and a white precipitate formed. THF was removed under reduced pressure and the residue partitioned between ethyl acetate and saturated sodium bicarbonate solution. The organic layer was washed with saturated sodium bicarbonate solution and water before drying over magnesium sulphate, filtration and removal of solvent to leave (4-benzhydrylpiperazin-1-yl)-acetic acid, methyl ester as a pale brown oil (2.80 g, 48%).

1. customa white precipitate formed
2. customTHF was removed under reduced pressure
3. customthe residue partitioned between ethyl acetate and saturated sodium bicarbonate solution
4. washThe organic layer was washed with saturated sodium bicarbonate solution and water
5. dry with materialbefore drying over magnesium sulphate, filtration and removal of solvent