Potassium Carbonate → HCID 18918799, compound

HRID 1291353Notes

Reaction equation

HRID 1291353 reaction equation
[CH:1]([C:4]1[C:9](=[O:10])[N:8]2[CH2:11][CH:12]=[N:13][C:7]2=[N:6][C:5]=1[CH3:14])([CH3:3])[CH3:2].[Cl:15][C:16]1[CH:31]=[CH:30][C:19]([C:20]([C:22]2[CH:29]=[CH:28][C:25]([CH2:26]Br)=[CH:24][CH:23]=2)=[O:21])=[CH:18][CH:17]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[Cl:15][C:16]1[CH:17]=[CH:18][C:19]([C:20]([C:22]2[CH:29]=[CH:28][C:25]([CH2:26][N:13]3[C:7]4=[N:6][C:5]([CH3:14])=[C:4]([CH:1]([CH3:3])[CH3:2])[C:9](=[O:10])[N:8]4[CH:11]=[CH:12]3)=[CH:24][CH:23]=2)=[O:21])=[CH:30][CH:31]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 98396514-(4-Chlorobenzoyl)benzyl bromideHCID 22373725HCID 22373725, compound

Product 1

HCID 18918799HCID 18918799, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of 6-isopropyl-7-methylimidazo[1,2-a]pyrimidin-5-one (0.400 g, 2.23 mmol) and 4-(4-chlorobenzoyl) benzyl bromide (0.762 g, 2.46 mmol) in DMF (15.0 ml) was added potassium carbonate (0.600 g, 4.50 mmol) and the mixture was stirred at room temperature overnight. The solvent was then distilled off and the residue was purified by silica gel column chromatography (methylene chloride: acetone=20:1) to provide a colorless amorphous solid.

Workup

  1. distillationThe solvent was then distilled off
  2. customthe residue was purified by silica gel column chromatography (methylene chloride: acetone=20:1)
  3. customto provide a colorless amorphous solid

Sources & evidence

ORD record
ord-2a78cdf18f30414fb2634c767773ba90
Source dataset
uspto-grants-1998_05
Patent number
US05753664

Reaction notes

Loading…