反应详情

To a mixture of 7.7 g (0.0416 mole) of 1H-imidazo[4,5-c]quinolin-4-ol and 50 mL of N,N-dimethylformamide was added in small portions 12 mL (0.13 mole) of phosphorus oxychloride. The mixture was heated on a steam bath for 1.5 hour, poured onto ice and basified with concentrated ammonium hydroxide. The solid precipitate was separated by filtration, washed with water and dried to provide 4-chloro-1H-imidazo[4,5-]quinoline as a tan powder corresponding to the product of Example 18.

1. temperatureThe mixture was heated on a steam bath for 1.5 hour
2. customThe solid precipitate was separated by filtration
3. washwashed with water
4. customdried