反应详情

To a mixture of 4-piperazin-1-yl-phenol (2 g, 11.2 mmol) and methyl 3-bromo-butyrate (2.03 g, 11.2 mmol) in DMF (5 mL) was added triethylamine (4.5 mL, 11.53 mmol) dropwise and the reaction mixture was stirred at ambient temperature overnight. The mixture was poured onto water and extracted with ethyl acetate (50 ml×3). The combined organic layers were washed with brine, dried over anhydrous Na2SO4 and evaporated under vacuum to dryness. The residue was purified by silica gel flash chromatography (1% methanol in CH2Cl2) to furnish the title compound (1.85 g, 59.3%); MS; m/z 279 (M+H).

1. additionThe mixture was poured onto water
2. extractionextracted with ethyl acetate (50 ml×3)
3. washThe combined organic layers were washed with brine
4. dry with materialdried over anhydrous Na2SO4
5. customevaporated under vacuum to dryness
6. customThe residue was purified by silica gel flash chromatography (1% methanol in CH2Cl2)