Water → HCID 17838733, compound

HRID 1293125Notes

Reaction equation

HRID 1293125 reaction equation
[CH2:1]([S:8][C:9]1[N:13]=[CH:12][N:11]([C:14](=[O:18])[N:15]([CH3:17])[CH3:16])[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.ClC1C=CC=C(C(OO)=[O:27])C=1.C(OCC)(=O)C.[OH2:36]>C(Cl)Cl>[CH2:1]([S:8]([C:9]1[N:13]=[CH:12][N:11]([C:14](=[O:18])[N:15]([CH3:16])[CH3:17])[N:10]=1)(=[O:27])=[O:36])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

6

Reactant 4

HCID 962WaterHCID 8857Ethyl AcetateHCID 70297m-Chloroperbenzoic acidHCID 17838758HCID 17838758, compound

Product 1

HCID 17838733HCID 17838733, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 3-benzylthio-1-dimethylcarbamoyl-1H-1,2,4-triazole (Example 1) (134 mg) in methylene chloride was added m-chloroperbenzoic acid (185 mg) with cooling it on ice, and the resulting mixture was stirred at room temperature for 4 hours. Ethyl acetate and water were added to the reaction mixture, which in turn was extracted with ethyl acetate. The organic layer was dried over sodium sulfate, and purified by a column chromatography (ethyl acetate/hexane=1/2) to yield the titled compound (69 mg) as a clear oil.

Workup

  1. temperaturewith cooling it on ice
  2. extractionwas extracted with ethyl acetate
  3. dry with materialThe organic layer was dried over sodium sulfate
  4. custompurified by a column chromatography (ethyl acetate/hexane=1/2)

Sources & evidence

ORD record
ord-5dcbe0a319274ca1a6c2738c07cec89b
Source dataset
uspto-grants-2007_07
Patent number
US07238720B2

Reaction notes

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