Dichloromethane → Trifluoromethanesulfonic anhydride

HRID 1295919Notes

Reaction equation

HRID 1295919 reaction equation
[F:1][C:2]([F:8])([F:7])[S:3]([O-:6])(=[O:5])=[O:4].ClCCl.C(N(CC)CC)C>N1C=CC=CC=1>[F:1][C:2]([F:8])([F:7])[S:3]([O:6][S:3]([C:2]([F:8])([F:7])[F:1])(=[O:5])=[O:4])(=[O:5])=[O:4]

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 2758875Trifluoromethanesulfonate

Product 1

HCID 67749Trifluoromethanesulfonic anhydride

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Step 2 is a step of conversion of hydroxyl to a trifluoromethanesulfonate (triflate). Compound (B3-c) may be obtained by reaction with trifluoromethanesulfonic anhydride in a solvent such as dichloromethane in the presence of a base such as triethylamine or pyridine, or by reaction with compound (B3-e) in the presence of triethylamine or dimethylaminopyridine.

Sources & evidence

ORD record
ord-0762649928824e08abb6335fd6a15e49
Source dataset
uspto-grants-2007_07
Patent number
US07244730B2

Reaction notes

Loading…