反应详情

Potassium carbonate (8.5 g, 62 mmol) and methyl iodide (8.8 g, 62 mmol) were added to a solution of 1-[3-amino-5-(tert-butyl)-4-methoxyphenyl]-1-ethanone (6 g, 21 mmol) in dimethylformamide (50 ml) and the mixture was stirred at room temperature for 13 hours. Ethyl acetate was added, the reaction mixture was washed with water and brine in that order and the organic layer was dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure and then the residue was purified by silica gel column chromatography (solvent: n-hexane-ethyl acetate) to yield the title compound (1.9 g) as a light yellow oil.

1. washthe reaction mixture was washed with water and brine in that order
2. dry with materialthe organic layer was dried over anhydrous magnesium sulfate
3. distillationThe solvent was distilled off under reduced pressure
4. customthe residue was purified by silica gel column chromatography (solvent: n-hexane-ethyl acetate)