反应详情

温度

65 °C

A mixture of 1-(3-amino-5-bromo-2-methoxyphenyl)-1-ethanone (12.8 g), iodomethane (60 mL), potassium carbonate (14.4 g) and N,N-dimethylformamide (200 mL) was stirred at 60 to 70° C. for 2 hours. Water was added to the mixture, extraction was performed with ethyl acetate, and the organic layer was washed with brine and then dried over anhydrous magnesium sulfate. After distilling off the solvent under reduced pressure, the residue was purified by silica gel column chromatography (solvent: n-hexane-ethyl acetate) to yield the title compound (9.6 g) as a yellow oil.

1. washthe organic layer was washed with brine
2. dry with materialdried over anhydrous magnesium sulfate
3. distillationAfter distilling off the solvent under reduced pressure
4. customthe residue was purified by silica gel column chromatography (solvent: n-hexane-ethyl acetate)