反应详情

1-[5-Bromo-3-(tert-butyl)-2-methoxyphenyl]piperazine (750 mg), potassium carbonate (411 mg) and ethyl bromoacetate (0.27 ml) were stirred in dimethylformamide (4 ml) at room temperature for one day. The reaction mixture was diluted with ethyl acetate, the insoluble portion was filtered off and then the concentrated residue was purified by silica gel column chromatography (solvent: n-hexane-ethyl acetate) to yield the title compound (715 mg) as a light red oil (75%).

1. filtrationthe insoluble portion was filtered off
2. customthe concentrated residue was purified by silica gel column chromatography (solvent: n-hexane-ethyl acetate)