Hydrochloric Acid → HCID 178443434, compound

HRID 1296526Notes

Reaction equation

HRID 1296526 reaction equation
O.[NH:2]1[C:6]([CH2:7][CH2:8][CH:9]2[CH2:18][CH2:17][CH:16]3[CH:11]([CH2:12][CH:13]([C:19]([OH:21])=[O:20])[NH:14][CH2:15]3)[CH2:10]2)=[N:5][N:4]=[N:3]1.Cl>C(O)CCCCCCCCC>[CH2:6]([O:20][C:19]([CH:13]1[CH2:12][CH:11]2[CH:16]([CH2:17][CH2:18][CH:9]([CH2:8][CH2:7][C:6]3[NH:2][N:3]=[N:4][N:5]=3)[CH2:10]2)[CH2:15][NH:14]1)=[O:21])[CH2:7][CH2:8][CH2:9][CH2:18][CH2:17][CH2:16][CH2:11][CH2:12][CH3:13]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178526951HCID 178526951, compound

Product 1

HCID 178443434HCID 178443434, compound

Reagents, catalysts & solvents 1

HCID 81741-DecanolSolvent

Procedure

A solution of 2.5 g (8.4 mmol) of 6-[2-(1H-Tetrazol-5-yl)-ethyl]-decahydro-isoquinoline-3-carboxylic acid monohydrate in 50 ml decyl alcohol saturated with hydrogen chloride (g) is heated at 120° C. overnight. The mixture is concentrated in vacuo and the residue purified by SPE (Oasis HLB) to afford the title compound.

Workup

  1. concentrationThe mixture is concentrated in vacuo
  2. customthe residue purified by SPE (Oasis HLB)

Sources & evidence

ORD record
ord-55361ea9e1a14da2a3d3920cabc41564
Source dataset
uspto-grants-2007_07
Patent number
US07247644B2

Reaction notes

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