Piperazine → HCID 18186810, compound

HRID 1296658Notes

Reaction equation

HRID 1296658 reaction equation
Cl[C:2]1[CH:7]=[N:6][CH:5]=[C:4]([O:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([O:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[CH:11]=2)[N:3]=1.O(C1C=C(C=CC=1)CO)C1C=CC=CC=1.[NH:38]1[CH2:43][CH2:42][NH:41][CH2:40][CH2:39]1.C([O-])([O-])=O.[K+].[K+]>>[O:16]([C:12]1[CH:11]=[C:10]([CH:15]=[CH:14][CH:13]=1)[CH2:9][O:8][C:4]1[CH:5]=[N:6][CH:7]=[C:2]([N:38]2[CH2:43][CH2:42][NH:41][CH2:40][CH2:39]2)[N:3]=1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Participants

5

Reactant 4

HCID 4837PiperazineHCID 11430Potassium CarbonateHCID 262953-Phenoxybenzyl alcoholHCID 18186827HCID 18186827, compound

Product 1

HCID 18186810HCID 18186810, compound

Procedure

The title compound was prepared according to the procedure of example 50, step 2, starting from 2-chloro-6-[(3-phenoxybenzyl)oxy]pyrazine (1.99 g, 6.36 mmol; obtained according to the procedure of example 50, step 1, starting from 3-phenoxybenzyl alcohol), piperazine (1.94 g, 22.5 mmol) and K2CO3 (0.88 g, 6.4 mmol). The yield of the title compound was 1.58 g (69%) which was obtained as an oil. Purity 100% (HPLC). MS m/z 363 (M+H)+. HRMS m/z calcd for C21H22N4O2 (M)+ 362.1743, found 362.1739.

Workup

  1. customThe title compound was prepared
  2. customobtained
  3. customwas obtained as an oil

Sources & evidence

ORD record
ord-4f3e963ed3474281b9c076612e7d64af
Source dataset
uspto-grants-2007_07
Patent number
US07247633B2

Reaction notes

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