Piperazine → HCID 9944677, compound

HRID 1296674Notes

Reaction equation

HRID 1296674 reaction equation
Cl[C:2]1[CH:7]=[N:6][CH:5]=[C:4]([O:8][CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([O:17][CH3:18])[CH:12]=2)[N:3]=1.COC1C=C(C=CC=1)CCO.[NH:30]1[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]1.C([O-])([O-])=O.[K+].[K+]>>[CH3:18][O:17][C:13]1[CH:12]=[C:11]([CH2:10][CH2:9][O:8][C:4]2[CH:5]=[N:6][CH:7]=[C:2]([N:30]3[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]3)[N:3]=2)[CH:16]=[CH:15][CH:14]=1

Participants

5

Reactant 4

HCID 4837PiperazineHCID 11430Potassium CarbonateHCID 787243-Methoxyphenethyl alcoholHCID 18186787HCID 18186787, compound

Product 1

HCID 9944677HCID 9944677, compound

Procedure

The title compound was prepared according to the procedure of example 50, step 2, starting from 2-chloro-6-[2-(3-methoxyphenyl)ethoxy]pyrazine (1.12 g, 4.23 mmol; obtained according to the procedure of example 50, step 1, starting from 3-methoxyphenethyl alcohol), piperazine (1.06 g, 12.3 mmol) and K2CO3 (0.585 g, 4.23 mmol). The yield of the title compound was 0.91 g (69%) which was obtained as light beige oil. HRMS m/z calcd for C17H22N4O2 (M)+ 314.1743, found 314.1759. Anal. (C17H22N4O2) C, H, N.

Workup

  1. customThe title compound was prepared
  2. customobtained
  3. customwas obtained as light beige oil

Sources & evidence

ORD record
ord-8a6af90540034067bdf7920bf5222812
Source dataset
uspto-grants-2007_07
Patent number
US07247633B2

Reaction notes

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