Diisopropylethylamine → HCID 10286478, compound

HRID 1296782Notes

Reaction equation

HRID 1296782 reaction equation
[N:1]12[CH2:8][CH2:7][CH:4]([CH2:5][CH2:6]1)[CH:3]([C:9]([Cl:11])=[O:10])[CH2:2]2.C(N(CC)C(C)C)(C)C.[N:21]1[C:30]2[C:25](=[CH:26][C:27]([NH2:31])=[CH:28][CH:29]=2)[N:24]=[CH:23][CH:22]=1>CN(C1C=CN=CC=1)C>[ClH:11].[N:21]1[C:30]2[C:25](=[CH:26][C:27]([NH:31][C:9]([CH:3]3[CH:4]4[CH2:7][CH2:8][N:1]([CH2:6][CH2:5]4)[CH2:2]3)=[O:10])=[CH:28][CH:29]=2)[N:24]=[CH:23][CH:22]=1

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 2378596-QuinoxalinamineHCID 114466161-Azabicyclo[2.2.2]octane-3-carbonyl chloride

Product 1

HCID 10286478HCID 10286478, compound

Reagents, catalysts & solvents 1

HCID 142844-(Dimethylamino)pyridineCatalyst

Procedure

In analogy to the method described in Example 2, 250 mg (2.57 mmol) of 3-quinuclidinecarbonyl chloride, 461 mg (3.57 mmol) of N,N-diisopropylethylamine, catalytic amounts of DMAP (approx. 1 mg) and 173 mg (1.19 mmol) of 6-quinoxalinylamine are reacted.

Workup

  1. customare reacted

Sources & evidence

ORD record
ord-e7b98ee681594d558f71bd129c002042
Source dataset
uspto-grants-2007_07
Patent number
US07247728B2

Reaction notes

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