4-Chlororesorcinol → HCID 58913639, compound

HRID 1296889Notes

Reaction equation

HRID 1296889 reaction equation
[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([OH:6])=[CH:4][C:3]=1[OH:9].[C:10]([CH2:12][CH2:13][CH2:14][O:15][C:16]1[CH:17]=[C:18]([CH2:22][C:23]([OH:25])=O)[CH:19]=[CH:20][CH:21]=1)#[N:11].P(Cl)(Cl)(Cl)(Cl)Cl.[CH3:32]N(C=O)C>>[Cl:1][C:2]1[CH:8]=[C:7]2[C:5](=[CH:4][C:3]=1[OH:9])[O:6][CH:32]=[C:22]([C:18]1[CH:17]=[C:16]([CH:21]=[CH:20][CH:19]=1)[O:15][CH2:14][CH2:13][CH2:12][C:10]#[N:11])[C:23]2=[O:25]

Participants

5

Reactant 4

HCID 17314-ChlororesorcinolHCID 6228DimethylformamideHCID 24819Phosphorus pentachlorideHCID 58913654HCID 58913654, compound

Product 1

HCID 58913639HCID 58913639, compound

Procedure

This compounds was synthesised in the same manner as described above. 4-Chlororesorcinol (0.33 g, 2.28 mmol), [3-(3-Cyano-propoxy)-phenyl]-acetic acid (0.5 g, 2.28 mmol), BF3Et2O (5 ml), PCl5 (0.71 g, 3.4 mmol), DMF (8 ml and 5 ml). Crude 4-[3-(6-Chloro-7-hydroxy-4-oxo-4H-chromen-3-yl)-phenoxy]-butyronitrile was obtained as an oil which was taken onto the next stage without further purification.

Workup

  1. customThis compounds was synthesised in the same manner

Sources & evidence

ORD record
ord-4e1c98c06e964944be5701a154866be2
Source dataset
uspto-grants-2007_07
Patent number
US07247734B2

Reaction notes

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