4-Chlororesorcinol → HCID 58913665, compound

HRID 1296890Notes

Reaction equation

HRID 1296890 reaction equation
[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([OH:6])=[CH:4][C:3]=1[OH:9].[C:10]([CH2:12][CH2:13][CH2:14][O:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[CH2:22][C:23]([OH:25])=O)#[N:11].P(Cl)(Cl)(Cl)(Cl)Cl.[CH3:32]N(C=O)C>>[Cl:1][C:2]1[CH:8]=[C:7]2[C:5](=[CH:4][C:3]=1[OH:9])[O:6][CH:32]=[C:22]([C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=1[O:15][CH2:14][CH2:13][CH2:12][C:10]#[N:11])[C:23]2=[O:25]

Participants

5

Reactant 4

HCID 17314-ChlororesorcinolHCID 6228DimethylformamideHCID 24819Phosphorus pentachlorideHCID 58913596HCID 58913596, compound

Product 1

HCID 58913665HCID 58913665, compound

Procedure

This compounds was synthesised in the same manner as described above. 4-Chlororesorcinol (0.125 g, 0.87 mmol), [2-(3-Cyano-propoxy)-phenyl]-acetic acid (0.19 g, 0.87 mmol), BF3Et2O (5 ml), PCl5 (0.27 g, 1.3 mmol), DMF (8 ml and 5 ml). Crude 4-[2-(6-Chloro-7-hydroxy-4-oxo-4H-chromen-3-yl)-phenoxy]-butyronitrile was obtained as an oil which was taken onto the next stage without further purification.

Workup

  1. customThis compounds was synthesised in the same manner

Sources & evidence

ORD record
ord-1b45ffa6f1014e32bd2def959c3f812d
Source dataset
uspto-grants-2007_07
Patent number
US07247734B2

Reaction notes

Loading…