4-Chlororesorcinol → HCID 58913663, compound

HRID 1296891Notes

Reaction equation

HRID 1296891 reaction equation
[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([OH:6])=[CH:4][C:3]=1[OH:9].[F:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[CH2:17][C:18]([OH:20])=O.P(Cl)(Cl)(Cl)(Cl)Cl.[CH3:27]N(C=O)C>>[Cl:1][C:2]1[CH:8]=[C:7]2[C:5](=[CH:4][C:3]=1[OH:9])[O:6][CH:27]=[C:17]([C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=1[F:10])[C:18]2=[O:20]

Participants

5

Reactant 4

HCID 17314-ChlororesorcinolHCID 6228DimethylformamideHCID 24819Phosphorus pentachlorideHCID 67979Benzeneacetic acid, 2-fluoro-

Product 1

HCID 58913663HCID 58913663, compound

Procedure

This compounds was synthesised in the same manner as described above. 4-Chlororesorcinol (1.889, 13.0 mmol), 2-fluorophenylacetic acid (2.0 g, 13 mmol), BF3Et2O (10 ml), PCl5 (4.0 g, 19.2 mmol), DMF (20 ml and 10 ml). The pale white precipitate formed was shown to contain the required compound and was taken directly onto the next stage.

Workup

  1. customThis compounds was synthesised in the same manner
  2. customThe pale white precipitate formed

Sources & evidence

ORD record
ord-10240e50173b4d62bed02d7168401a77
Source dataset
uspto-grants-2007_07
Patent number
US07247734B2

Reaction notes

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