Acetic Acid → HCID 69427723, compound

HRID 1297033Notes

Reaction equation

HRID 1297033 reaction equation
[C:1]([O:7][CH2:8][CH2:9][C:10]#[N:11])(=[O:6])[CH2:2][C:3]([CH3:5])=[O:4].[Cl:12][C:13]1[CH:14]=[C:15]([CH:18]=[CH:19][CH:20]=1)[CH:16]=O.C(O)(=O)C.N1CCCCC1>CC(O)C>[C:3]([C:2](=[CH:16][C:15]1[CH:18]=[CH:19][CH:20]=[C:13]([Cl:12])[CH:14]=1)[C:1]([O:7][CH2:8][CH2:9][C:10]#[N:11])=[O:6])(=[O:4])[CH3:5]

Participants

6

Reactant 4

HCID 176Acetic AcidHCID 8082PiperidineHCID 114773-ChlorobenzaldehydeHCID 123604062-Cyanoethyl 3-oxobutanoate

Product 1

HCID 69427723HCID 69427723, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

1.00 g (6.45 mmol) of 2-cyanoethyl acetoacetate and 730 μl (6.44 mmol) of 3-chlorobenzaldehyde were stirred in the presence of a catalytic amount of acetic acid and piperidine in 100 ml of 2-propanol at room temperature overnight. The solvent was evaporated under reduced pressure to obtain the title compound.

Workup

  1. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-be115c3215564dbc99bbe588d9f59e94
Source dataset
uspto-grants-2007_07
Patent number
US07247645B2

Reaction notes

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