Piperidine → HCID 86586137, compound

HRID 1297040Notes

Reaction equation

HRID 1297040 reaction equation
[C:1]([CH2:3][CH2:4][O:5][C:6]([C:8]1[CH:9]=[C:10]([CH:13]=[CH:14][CH:15]=1)[CH:11]=O)=[O:7])#[N:2].[CH2:16]([N:23]1[CH2:29][CH2:28][CH2:27][N:26]([C:30](=[O:35])[CH2:31][C:32](=[O:34])[CH3:33])[CH2:25][CH2:24]1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.N1CCCCC1.C(OCC)(=O)C>C1C=CC=CC=1>[CH2:16]([N:23]1[CH2:29][CH2:28][CH2:27][N:26]([C:30]([C:31]([C:32](=[O:34])[CH3:33])=[CH:11][C:10]2[CH:9]=[C:8]([CH:15]=[CH:14][CH:13]=2)[C:6]([O:5][CH2:4][CH2:3][C:1]#[N:2])=[O:7])=[O:35])[CH2:25][CH2:24]1)[C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

Participants

6

Reactant 4

HCID 8082PiperidineHCID 8857Ethyl AcetateHCID 17825639HCID 17825639, compoundHCID 17825650HCID 17825650, compound

Product 1

HCID 86586137HCID 86586137, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

1.12 g (5.00 mmol) of 3-(2-cyanoethoxycarbonyl)benzaldehyde, 1.38 g (5.03 mmol) of 1-(4-benzyl[1,4]-diazepane-1-yl)butane-1,3-dion and 0.05 ml (0.51 mmol) of piperidine were stirred in 50 ml of benzene at 105° C. overnight. Ethyl acetate was added to the reaction mixture. After drying over anhydrous sodium sulfate, the product was concentrated under reduced pressure to obtain the title compound.

Workup

  1. dry with materialAfter drying over anhydrous sodium sulfate
  2. concentrationthe product was concentrated under reduced pressure

Sources & evidence

ORD record
ord-cd870e1b06c846c284f8197012ae3b3c
Source dataset
uspto-grants-2007_07
Patent number
US07247645B2

Reaction notes

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