Sodium hydride → 7,8-Dimethoxy-1-n-propyl-3,4-dihydro-1h-1,4-benzodiazepine-2,5-dione

HRID 1297095Notes

Reaction equation

HRID 1297095 reaction equation
[CH3:1][O:2][C:3]1[C:4]([O:16][CH3:17])=[CH:5][C:6]2[NH:12][C:11](=[O:13])[CH2:10][NH:9][C:8](=[O:14])[C:7]=2[CH:15]=1.[H-].[Na+].[CH2:20](I)[CH2:21][CH3:22]>CN(C=O)C>[CH3:1][O:2][C:3]1[C:4]([O:16][CH3:17])=[CH:5][C:6]2[N:12]([CH2:20][CH2:21][CH3:22])[C:11](=[O:13])[CH2:10][NH:9][C:8](=[O:14])[C:7]=2[CH:15]=1

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 336431-IodopropaneHCID 694609827,8-dimethoxy-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione

Product 1

HCID 694638067,8-Dimethoxy-1-n-propyl-3,4-dihydro-1h-1,4-benzodiazepine-2,5-dioneYield 65%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of 723 mg (3.06 mmol) of 7,8-dimethoxy-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione (XVIIab), in 6 ml of anhydrous DMF, add under an inert atmosphere 134 mg (3.37 mmol) of 60% NaH in oil. After 10 minutes at room temperature, add dropwise 328 μl (3.37 mmol) of n-PrI. Allow to stand at room temperature for 3 hours. Add 40 ml of a water-ice mixture. Filter the precipitate and wash twice with 1 ml of EtOH and 3 ml of Et2O. One obtains 320 mg of the abovenamed product in the form of a white powder. Yield: 65%. 1H-NMR (DMSO, 200 MHz): d 0.66–0.73 (m, 3H, CH2CH3), 1.27–1.39 (m, 2H, CH2CH3), 3.30–4.22 (m, 10H, CH2+CH2+2×OCH3), 6.97 (s, 1H Ar), 7.13 (s, 1H Ar), 8.56 (s, 1H, NH).

Workup

  1. waitto stand at room temperature for 3 hours
  2. filtrationFilter the precipitate
  3. washwash twice with 1 ml of EtOH and 3 ml of Et2O

Sources & evidence

ORD record
ord-ff3e351912cf4ae08a539e3f9785bb04
Source dataset
uspto-grants-2007_07
Patent number
US07250410B2

Reaction notes

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