Tri-o-tolylphosphine → (E)-N-methyl-3-(8-oxo-6,7,8,9-tetrahydro-5H-pyrido[2,3-b]azepin-3-yl)acrylamide

HRID 1297448Notes

Reaction equation

HRID 1297448 reaction equation
Br[C:2]1[CH:13]=[N:12][C:5]2[NH:6][C:7](=[O:11])[CH2:8][CH2:9][CH2:10][C:4]=2[CH:3]=1.CC1NC2C(C=1[CH2:24][N:25](C)[C:26](=[O:29])[CH:27]=[CH2:28])=CC=CC=2.C1(C)C=CC=CC=1P(C1C=CC=CC=1C)C1C=CC=CC=1C.C(N(C(C)C)CC)(C)C>C(#N)CC.CC([O-])=O.CC([O-])=O.[Pd+2]>[CH3:24][NH:25][C:26](=[O:29])/[CH:27]=[CH:28]/[C:2]1[CH:13]=[N:12][C:5]2[NH:6][C:7](=[O:11])[CH2:8][CH2:9][CH2:10][C:4]=2[CH:3]=1

Participants

7

Reactant 4

HCID 80271Tri-o-tolylphosphineHCID 81531DiisopropylethylamineHCID 221390243-Bromo-5,6,7,9-tetrahydro-pyrido[2,3-b]azepin-8-oneHCID 22139057N-(2-methyl-1H-indol-3-ylmethyl)-N-methylacrylamide

Product 1

HCID 10377212(E)-N-methyl-3-(8-oxo-6,7,8,9-tetrahydro-5H-pyrido[2,3-b]azepin-3-yl)acrylamideYield 57.1%

Reagents, catalysts & solvents 2

HCID 167845palladium(II) acetateCatalystHCID 7854PropionitrileSolvent

Procedure

A solution of 3-bromo-5,6,7,9-tetrahydro-pyrido[2,3-b]azepin-8-one (0.60 g, 2.50 mmole), N-(2-methyl-1H-indol-3-ylmethyl)-N-methylacrylamide (0.85 g, 3.75 mmole), Pd(OAc)2 (0.06 g, 0.25 mmole), tri-ortho-tolylphosphine (0.15 g, 0.50 mmole) and diisopropylethylamine (0.87 mL, 5.00 mmole) in propionitrile (50 mL) was deoxygenated, then was and heated to reflux under a N2 overnight. The dark mixture was filtered through a pad of celite®, and the filter pad was rinsed with acetonitrile (200 mL). The filtrate was concentrated in vacuo, and the residue was purified by flash chromatography on silica gel (10% MeOH/CHCl3). The title compound (0.35 g. 35%) was obtained as a light tan solid after drying in vacuo: MS (ES) m/e 246 (M+H)+.

Workup

  1. temperatureheated
  2. temperatureto reflux under a N2 overnight
  3. filtrationThe dark mixture was filtered through a pad of celite®
  4. washthe filter pad was rinsed with acetonitrile (200 mL)
  5. concentrationThe filtrate was concentrated in vacuo
  6. customthe residue was purified by flash chromatography on silica gel (10% MeOH/CHCl3)

Sources & evidence

ORD record
ord-d1e8de90b12e470893b887a959ab6226
Source dataset
uspto-grants-2007_07
Patent number
US07250424B2

Reaction notes

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