Isobutanol → HCID 58585800, compound

HRID 1297720Notes

Reaction equation

HRID 1297720 reaction equation
[CH3:1][CH:2]([CH3:5])[CH2:3][OH:4].Cl[C:7]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([I:17])[CH:15]=2)[N:10]=[CH:9][C:8]=1[C:18]#[N:19].[H-].[K+]>C1COCC1>[I:17][C:14]1[CH:15]=[C:16]2[C:11](=[CH:12][CH:13]=1)[N:10]=[CH:9][C:8]([C:18]#[N:19])=[C:7]2[O:4][CH2:3][CH:2]([CH3:5])[CH3:1]

Participants

5

Reactant 3

HCID 6560IsobutanolHCID 82127Potassium hydrideHCID 224667694-Chloro-6-iodoquinoline-3-carbonitrile

Product 1

HCID 58585800HCID 58585800, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Similar procedure as described in example 28a was used, starting from 2-methyl-propan-1-ol, 4-chloro-6-iodo-quinoline-3-carbonitrile (example 14c) and potassium hydride in a solvent system of THF to give 6-iodo-4-isobutoxy-quinoline-3-carbonitrile. LC-MS m/e 353(MH+).

Sources & evidence

ORD record
ord-f127a6a8b8e545f89f979231e332675b
Source dataset
uspto-grants-2007_07
Patent number
US07250515B2

Reaction notes

Loading…