Hydrochloric Acid → HCID 69256214, compound

HRID 130349Notes

Reaction equation

HRID 130349 reaction equation
O.Cl.[N+:3]([C:6]1[CH:7]=[C:8]([CH:21]=[CH:22][CH:23]=1)[O:9][C:10]1[CH:15]=[CH:14][C:13]([CH2:16][C:17]([O:19][CH3:20])=[O:18])=[CH:12][CH:11]=1)([O-])=O>C(O)C.[Fe]>[NH2:3][C:6]1[CH:7]=[C:8]([CH:21]=[CH:22][CH:23]=1)[O:9][C:10]1[CH:11]=[CH:12][C:13]([CH2:16][C:17]([O:19][CH3:20])=[O:18])=[CH:14][CH:15]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 69257481HCID 69257481, compound

Product 1

HCID 69256214HCID 69256214, compound

Reagents, catalysts & solvents 2

HCID 23925IronCatalystHCID 702EthanolSolvent

Conditions

Temperature
95 °C

Procedure

Iron powder (5.03 g; 56 mmol), water (5 mL) and hydrochloric acid (0.1 mL; 36 mmol) are added consecutively to a solution of methyl 2-[4-(3-nitrophenoxy)phenyl]acetate (1.3 g; 4.5 mmol) in ethanol (20 mL). After stirring at 95° C. for four hours, the solid is filtered while still hot and the filtrate is stripped of solvent in vacuo to yield methyl 2-[4-(3-aminophenoxy)phenyl]acetate as an oil. Yield: 1.1 g (95%).

Workup

  1. filtrationthe solid is filtered while still hot and the filtrate

Sources & evidence

ORD record
ord-48f3f42ff7164f808df73360ae9cff62
Source dataset
uspto-grants-2008_06
Patent number
US07381736B2

Reaction notes

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