反应详情

150 mg of methyl 5-methanesulfonyl-2-methyl-4-(3-pentafluorosulfanyl-phenylamino)benzoate (example 5 c) were dissolved in 2 ml of DMF (anhydrous), 13.5 mg of NaH were added, and the mixture was stirred at RT for 15 minutes. Then 15 μl of CH3I were injected and the mixture was left to stand at RT for 18 h. The reaction mixture was then poured into 10 ml of a saturated aqueous NaHCO3 solution and extracted with 40 ml of EA. The organic phase was subsequently washed with 10 ml of water. Drying over MgSO4 and removal of the solvent in vacuo resulted in 120 mg of a pale yellow foam.

1. waitthe mixture was left
2. waitto stand at RT for 18 h
3. extractionextracted with 40 ml of EA
4. washThe organic phase was subsequently washed with 10 ml of water
5. dry with materialDrying over MgSO4 and removal of the solvent in vacuo