反应详情

A solution of 4-hydroxy-3-methylbenzaldehyde (1.0 equiv) in DMF (0.2 M solution) was treated with K2CO3 (1.5 equiv) and 6-chloronicotinamide (1.0 equiv). The reaction mixture was placed inside the microwave oven and then irradiated for 5 min. Upon completion of the reaction, the mixture was cooled, poured into H2O and extracted with ethyl acetate, and the combined organic layers were washed twice with water and brine. After drying the extracts over magnesium sulfate and evaporation under vacuum the crude product was purified by silica gel chromatography using CHCl3: EtOH 7%: NH4OH 0.7% to afford the title compound as a solid.

1. customirradiated for 5 min
2. customUpon completion of the reaction
3. temperaturethe mixture was cooled
4. extractionextracted with ethyl acetate
5. washthe combined organic layers were washed twice with water and brine
6. customAfter drying the extracts
7. customover magnesium sulfate and evaporation under vacuum the crude product
8. customwas purified by silica gel chromatography