反应详情

4-Hydroxy benzaldehyde (1 equiv), 2-chloro-4-fluorobenzonitrile (1 equiv) and K2CO3 (2.5 equiv) in anhydrous DMF (0.2 M) were heated at 110° C. under nitrogen during 1 hour (the reaction can be monitored by tlc). After cooling down to room temperature, the reaction mixture was poured into water and extracted with ethyl acetate (3×50 mL). The combined organic layer was dried over Na2SO4, filtered and concentrated under vacuum (toluene was added to aid DMF evaporation). The crude mixture was purified by flash chromatography using hexanes/ethyl acetate (4:1) as eluent.

1. customthe reaction
2. extractionextracted with ethyl acetate (3×50 mL)
3. dry with materialThe combined organic layer was dried over Na2SO4
4. filtrationfiltered
5. concentrationconcentrated under vacuum (toluene was added to aid DMF evaporation)
6. customThe crude mixture was purified by flash chromatography