反应详情

6-chloro-3-methyl uracil (10 g) and potassium carbonate (10.34 g) in DMF (70 ml) under nitrogen was treated with n-propyl iodide (25.4 g) and heated at reflux for 8 h. The reaction 30 was cooled and then poured into water (700 ml) and extracted with ethyl acetate. The combined organics were dried and evaporated in vacuo to afford the subtitle compound an orange oil, 17.52 g. δ 1HCDCl3 0.98 (3H, t), 1.74 (2H, sextet), 3.33 (3H, s), 4.02 (2H, t), 8.02 (1H, s).

1. temperatureheated
2. temperatureat reflux for 8 h
3. customThe reaction 30
4. temperaturewas cooled
5. extractionextracted with ethyl acetate
6. customThe combined organics were dried
7. customevaporated in vacuo