Hydrochloric Acid → HCID 68804457, compound

HRID 131581Notes

Reaction equation

HRID 131581 reaction equation
[OH-].[Na+:2].[CH3:3][N:4]1[C:9](=[O:10])[C:8]2[C:11]([C:26]([O:28]C)=[O:27])=[C:12]([CH2:14][N:15]3[C:23]4[C:18](=[N:19][CH:20]=[CH:21][CH:22]=4)[N:17]=[C:16]3[S:24][CH3:25])[S:13][C:7]=2[N:6]([CH2:30][CH:31]([CH3:33])[CH3:32])[C:5]1=[O:34].CO.Cl>O1CCCC1>[CH3:3][N:4]1[C:9](=[O:10])[C:8]2[C:11]([C:26]([O-:28])=[O:27])=[C:12]([CH2:14][N:15]3[C:23]4[C:18](=[N:19][CH:20]=[CH:21][CH:22]=4)[N:17]=[C:16]3[S:24][CH3:25])[S:13][C:7]=2[N:6]([CH2:30][CH:31]([CH3:32])[CH3:33])[C:5]1=[O:34].[Na+:2]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14798Sodium HydroxideHCID 86622713HCID 86622713, compound

Product 1

HCID 68804457HCID 68804457, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Sodium hydroxide (0.8 ml, 1M) was added to a solution of the product of example 37 part b) (190 mg) in tetrahydrofuran under nitrogen. Methanol was added to solubilise the solution and the reaction mixture was stirred at room temperature for 3 hours. HCl (0.4 ml, 2M) was added to neutralise the solution and the mixture was concentrated in vacuo to give the title-compound. MS(ES) 460 [M+H]+

Workup

  1. concentrationthe mixture was concentrated in vacuo
  2. customto give the title-compound

Sources & evidence

ORD record
ord-ec0b0f5a817442cfa5c7272fae500c5d
Source dataset
uspto-grants-2008_06
Patent number
US07384950B2

Reaction notes

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