Di-tert-butyl dicarbonate → HCID 67562678, compound

HRID 132806Notes

Reaction equation

HRID 132806 reaction equation
[NH2:1][C@@H:2]([CH2:7][C:8]1[CH:13]=[C:12]([F:14])[CH:11]=[C:10]([F:15])[CH:9]=1)[C@H:3]([OH:6])[CH2:4][OH:5].[O:16](C(OC(C)(C)C)=O)[C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=O>C1COCC1>[F:15][C:10]1[CH:9]=[C:8]([CH:13]=[C:12]([F:14])[CH:11]=1)[CH2:7][C@H:2]([NH:1][C:17](=[O:16])[O:19][C:20]([CH3:23])([CH3:22])[CH3:21])[C@H:3]([OH:6])[CH2:4][OH:5]

Participants

4

Reactant 2

HCID 90495Di-tert-butyl dicarbonateHCID 597347901,2-Butanediol, 3-amino-4-(3,5-difluorophenyl)-, (2S,3S)-

Product 1

HCID 67562678HCID 67562678, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Aminodiol 27 was dissolved in THF and BOC2O was added and stirred overnight. Solvent removal afforded 28, which was carried directly into the next step; analytical sample m.p.=122°.

Workup

  1. customSolvent removal

Sources & evidence

ORD record
ord-ac42f5607e114f48b21b8147b57a8f2c
Source dataset
uspto-grants-2008_06
Patent number
US07388118B2

Reaction notes

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