Hydrochloric Acid → HCID 86602342, compound

HRID 133181Notes

Reaction equation

HRID 133181 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH:5]=[C:6]([CH3:8])[CH:7]=1.[H-].[Na+].Cl.[CH:18](OCC)=[O:19]>>[CH3:1][C:2]1[CH:3]=[C:4]([C:9](=[CH:18][OH:19])[C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH:5]=[C:6]([CH3:8])[CH:7]=1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 8025Ethyl formateHCID 24758Sodium hydrideHCID 7021465Ethyl 3,5-dimethylphenylacetate

Product 1

HCID 86602342HCID 86602342, compound

Procedure

10 ml of ethyl 2-(3,5-dimethylphenyl)acetate are dissolved in 80 ml of ethyl formate. 5 g of 50% NaH are added portionwise and then the mixture is stirred at AT for 12 hours. The mixture is poured onto a 1N HCl solution and then extraction is carried out with AcOEt. The organic phase is evaporated to produce the expected compound, used as is in the following stage.

Workup

  1. extractionextraction
  2. customThe organic phase is evaporated

Sources & evidence

ORD record
ord-ae943f8b92be47008aa65b0dfaaa1682
Source dataset
uspto-grants-2008_06
Patent number
US07390818B2

Reaction notes

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