反应详情

温度

80 °C

3.72 g of tin(II) chloride dihydrate was added to a dimethylformamide (16 ml) suspension of 1.52 g of N-(4-benzyloxy-5-(2-fluorophenoxy)-2-nitrophenyl)pyrazinecarboxamide, and the reaction liquid was stirred overnight at 80° C. The reaction liquid was diluted with ethyl acetate, washed with aqueous saturated sodium bicarbonate, water and saturated saline in order, and dried with anhydrous magnesium sulfate. The solvent was evaporated away under reduced pressure, and the resulting residue was washed with a mixed solvent of ethyl acetate and hexane to obtain the entitled compound as a yellow solid.

1. customthe reaction liquid
2. customThe reaction liquid
3. washwashed with aqueous saturated sodium bicarbonate, water and saturated saline in order
4. dry with materialdried with anhydrous magnesium sulfate
5. customThe solvent was evaporated away under reduced pressure
6. washthe resulting residue was washed with a mixed solvent of ethyl acetate and hexane