反应详情

To a solution of 1.5 g (9.7 mmol) of 2-chloroacetophenone in 10 mL of MeCN, 0.7 g (10.3 mmol) of pyrazole was added. After all the solids dissolved, 1.4 g (10.1 mmol) of ground K2CO3 was added and the mixture was stirred for 5 h. The reaction was diluted with EtOAc, filtered, and the solid was washed with EtOAc. The filtrate was washed with water and brine, then was dried and concentrated. The residue was chromatographed on a flash column using a gradient of 10-50% EtOAc-hexane to isolate desired product.

1. dissolutionAfter all the solids dissolved
2. filtrationfiltered
3. washthe solid was washed with EtOAc
4. washThe filtrate was washed with water and brine
5. customwas dried
6. concentrationconcentrated
7. customThe residue was chromatographed on a flash column